Roche Cobas 4800 System System Manual Download Page 1

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Summary of Contents for Cobas 4800 System

Page 1: ...cobas 4800 System System Manual Software Version 2 1...

Page 2: ...plification and detection of specific targets from human samples It is important that the operator reads this manual and the test specific Operator s Manual thoroughly before using the system The syst...

Page 3: ...0 C Complies with the IVD directive 98 79 EG Issued by underwriters laboratories mc UL for Canada and the US C JS Roche Molecular Systems mc 1080 U S Highway South Branchburg NJ 08876 1760 USA Made i...

Page 4: ...cobas 4800 System System Manual Roche Diagnostics 4 System Manual Version 1 0...

Page 5: ...enance Safety information Instrument maintenance Analvzer maintenance Roche Diagnostics System Manual Version 1 0 103 104 115 Troubleshooting 7 3 5 7 7 7 7 System description 7 Troubleshooting Overvie...

Page 6: ...cobas 4800 System System I 4anual Roche Diagnostics System Manual Version 1 0 6...

Page 7: ...at the end of the manual Where to find information In addition to this manual the following documents are also provided to assist in finding desired information quickly Test specfic Operator Manuals F...

Page 8: ...st the A frequency response curve This curve approximates the audible range of the human ear DIL Diluent DWP Deepweil Plate EC European community e g exempli gratia for example EMC ElectroMagnetic Com...

Page 9: ...rn Manual Roche Diagnostics System Manual Version 1 0 Product name Abbreviation cobas 4800 software software cobas x 480 instrument instrument cobas z 480 analyzer analyzer cobas 4800 System system Ta...

Page 10: ...cobas 4800 System Systeni Manual Roche Diagnosti System Manual Version 1 0 10...

Page 11: ...System description 1 General safety information 13 2 Overview 29 3 Hardware 37 4 Software 71...

Page 12: ......

Page 13: ...us materials 19 Waste 19 Explosion and fire risk 20 Caution messages 20 Mechanical safety 20 Reagents and consumables 21 Interfering substances in samples 21 Evaporation of samples or reagents 21 Inco...

Page 14: ...information cobas 4800 System Table ofcontents System Manual Disposal 27 Disposal of the instrument 27 Disposal of the analyzer 27 Disposal of control unit components 27 Roche fliagnostics 14 System M...

Page 15: ...provided elsewhere in the document These symbols and signal words are used for specific hazards WARNING 1 Indicates a hazardous situation which if not avoided could result in death or serious WARNING...

Page 16: ...h side shields fluid resistant lab coat and approved disposable gloves Wear a face shield ifthere is a chance of splash or splatter Accuracy precision of measured Do not use reagents that have exceede...

Page 17: ...rruptible power supply UPS is strongly recommended Check the UPS regularly to make sure it functions properly 1f there is a power failure the analyzer is disconnected from the control unit The display...

Page 18: ...Do not attempt to work in any electronic compartment WARNING Do not remove any cover of the instrument or analyzer other than those specified in this manual or the test specific Operators Manual Do no...

Page 19: ...ry due to sharp objects When wiping sharp objects use several layers of gauze WARNING Be careful to not puncture yourself Be sure to wear appropriate protective equipment for example gloves Waste Infe...

Page 20: ...ay result in minor or moderate injury Mechanical safety Personal injury due to contact with moving parts The pipetting head of the instrument moves rapidly during sample preparation The main CAUTION c...

Page 21: ...ed reagents should not be used on other cobas 4800 systems Invalid results due to expired reagents and consumables Data obtained using expired reagents and consumables are not reliable Reagents are CA...

Page 22: ...s of analytes or reagents may be carried over from one test to the next Take adequate measures to prevent carryover and to avoid potentially false results When any indication of potential sources of c...

Page 23: ...ructed to do so by a Roche Service representative It additional software is required contact your Roche Service representative to ensure validation of the software in question Do not use the USB ports...

Page 24: ...port Spillage Malfunction due to spilled liquid Any liquid spilled on the instrument or analyzer may result in malfunction or damage of the instrument or analyzer Do not place samples reagents or any...

Page 25: ...nnel For replacement labels contact your local Roche representative Safety labels on the instrument A Pipetting Arm Do not move pipetting arm by hand B Biohazard warning 1 4r Instrument deck may conta...

Page 26: ...in of the microweil Do not touch hot surfaces plate loader On the surface of the block cycler cover On the surface of the block cycler unit On the Xenon lamp unit Biohazard warning On the margin of th...

Page 27: ...n is required before reuse recycling or disposal of the analyzer 1f you want to dispose of the analyzer contact your Roche representative Disposal of control unit components Disposal of control unit c...

Page 28: ...1 General safety information cobas 4800 System Disposal Systeni Mamal Roche Diagnostics 28 System Manual Version 1 0...

Page 29: ...pter you get a basic overview about the whole system inciuding the instrument the analyzer and the software In this chapter Chapter System overview 31 Instrument 32 Analyzer 33 System software and con...

Page 30: ...2 Overview cobas 4800 System Table ofcontents Systern Manual Roche Diagnostics ao System Manual Version 1 0...

Page 31: ...ration Amplification and detection using real time PCR Minimal hands on time Multiple sample types Multiple tests targets Intuitive operation by an easy to use workflow wizard The system combines the...

Page 32: ...reagents After sample preparation the microweli plate with the PCR ready samples is unloaded sealed and transferred to the analyzer for amplification and detection using real time PCR The procedure fo...

Page 33: ...i iew Analyzer Roche Diagnostics System Manual Version 1 0 The analyzer utilizes fluorescence signal to detect nucleic acids amplified by using real time PCR methodologv Sealing loading and unloading...

Page 34: ...s as well as sample barcodes to set up the ivork order file For details about the control unit and the hand held barcode reader see Control unit p 69 The system can be connected to a Laboratory inform...

Page 35: ...e work orders for a PCR Only run The LIS connection if the LIS is present or not can be configured by the lab manager or administrator The LIS time out maximal time between an LIS query and answer can...

Page 36: ...2 Overview cobas 4800 System Systern overview Systern Man ial Roche Diagnostics 36 System Manual Version 1 0...

Page 37: ...e carriers 50 Reagent carriers 53 Plate carrier 55 Tip rack carriers 55 Stationary carrier 56 Consumables 58 Pipetting tips 58 Reagent reservoirs 58 Deepweli plate 59 Microweli plate 60 Consumables fo...

Page 38: ...3 Hardware cobas 4800 System Table ofcontents Systens Manual Roche Diagnostics 38 System Manual Version to...

Page 39: ...g 2 Generic binding washing and elution 3 Working master mix preparation and PCR setup Depending on the test the instrument is able to process up to 96 samples 94 patient specimens plus two controls i...

Page 40: ...ing maintenance Always close the front cover when you have finished maintenance work During a run the front cover must be closed Loss of materials due to forced opening of front cover The front cover...

Page 41: ...y Carrier on board at that No action necessary position Green light blinking Indicates the track positions Place the carrier at the in which the carrier must be indicated positions on the loaded autol...

Page 42: ...k layout Track positions test specijic The following table summarizes the track positions on the instrument deck Track position Used for carrier 1 6 Platecarrier 7 10 Not used 11 16 Left tip carrier 1...

Page 43: ...d disposables A Inserted carrierwaiting to be loaded B Slide block C Track position stamped on the autoload tray Figure 3 5 Autoload unit with autoload tray and autoloader The autoload tray contains s...

Page 44: ...sum Code 128 subset B and C with check sum GTIN inciuding JAN with check sum This barcode type is not enabled by default 1f you require this barcode type contact Roche Service Interleaved 2 of 5 with...

Page 45: ...each pipetting channel at the beginning of a pipetting cycle The pipetting tip is ejected into the tip solid waste bag at the completion of pipetting for that cycle Figure 3 7 Pipetting arm of instru...

Page 46: ...he pipetting arm Figure 3 8 ISWAP Roche Diagnostics The instrument uses eight teaching needies to automatically check and adjust if necessary z positioning and over and under pressure of each pipettin...

Page 47: ...en ejected by the pipetting arm The instrument can be installed on either a bench top or on a trolley that accommodates a larger solid waste bag 1f the instrument is installed on a bench top a small s...

Page 48: ...y are full 1f required replace the waste chute in the same way as the small tip solid waste bag 1f required fold up a new waste box as indicated in Figure 3 12 Folding up a new waste box p 49 For deta...

Page 49: ...n this case it is not possible to start the run The liquid vaste is emptied during daily or weekly maintenance The liquid waste container is reusable For details about emptying the liquid waste contai...

Page 50: ...Different sample carriers allow the use of samples in primary and secondary tubes Depending on the test up to 94 patient specimens can be loaded onto the instrument per run The sample barcodes must f...

Page 51: ...ers Barcode dirnensions c B c U EL1 A A Label length max 80 mm B Code Ienght max 74 mm C Quiet zone min 3 mm D Label width min 12 mm E Code width min 12 mm F Distance from code to label edge max 1 mm...

Page 52: ...carrier can fall over and cause injury or contamination Handle 1 track carriers with particular care position them on the autoload tray or place several carriers together to minimize this risk Roche D...

Page 53: ...two sizes 200 mL reagent reservoir carrier for 200 mL reservoirs 50 mL reagent reservoir carrier for 50 mL reservoirs The required reagents are poured into the reagent reservoirs which are then place...

Page 54: ...ier The reagent barcodes must face to the right of the carrier For details about reagent placement on reagent carriers refer to the test specific Operator s Manual The reagent carrier is the same carr...

Page 55: ...eepweil plate according to the local regulations unless further off the system use is intended Tip rack carriers Figure 3 23 Plate carrier The tip rack carriers hold the tip racks with the disposable...

Page 56: ...r hoids four units heater shaker unit magnet plate deepweli plate holder microwell plate holder A Microweli plate holder B Deepweil plate holder Figure 3 25 Stationary carrier Heater shaker unit The h...

Page 57: ...ugging It A P Power switch of the heater shaker unit Figure 3 26 Controller box for heater shaker unit Magnetpiate The magnet plate immobilizes magnetic glass particles during sample processing Be awa...

Page 58: ...ip rack carriers see Tip rack carriers p 55 NOTICE Instrument damage due to use of unsuitable tips Non Roche tips may cause contamination or damage pipetting channels Use only disposable tips that are...

Page 59: ...ement to minimize the risk of spiashing and resulting reagent loss Do not pour reagents into reservoirs that are already placed onto a reagent rack Always follow the scan scan pour place principle Do...

Page 60: ...ate using the sealing film iJ For details about sealing of the microweli plate refer to the test specific Operator s Manual Roche Diagnostics The microweil plate is barcoded and designed for one time...

Page 61: ...en they are full For additional details see Wiiste station p 47 You can use specific tubes when a secondary tube is needed on the instrument for a 24 position or 32 position sample carrier For details...

Page 62: ...13 to 158 F Humidity Running conditions 15 85 without condensation Noise 65dBA Pollution Level 2 EN 61010 1 IEC 60664 1 Altitude 30 2000 m 100 6500 ft above sea level Table 3 8 Environmental conditio...

Page 63: ...check characters Code density tolerance Best reading performance with X dimension between 0 19 mm 0 0075 in and 0 25 mm 0 01 in Quiet zone 10 times the X dimension atleast 3 mm 0 12 in Print quality P...

Page 64: ...131 F Storage temperature Microweil plate and deepwell plate are designed to be stored at a temperature range between 15 C to 25 C 59 F to 77 F Pipetting tips can be stored al a temperature range betw...

Page 65: ...perly with the self adhesive sealing film Sealing the plate is crucial to eliminate evaporation at high temperatures Unsealed microwell plates may damage the analyzer or lead to incorrect results Alwa...

Page 66: ...it B Hausing C Status LED D Laad buttan H Filter wheels 1 Black cycler daar apen with ventilation H B F Micrawell plate laader G Detectian unit E Thermal block cycler fans Figure 3 33 Building blocks...

Page 67: ...ensure that all the information contained in these specifications is correct at the time of printing However Roche reserves the right to make any changes necessary without notice as part of ongoing p...

Page 68: ...Technical detail Temperature Running conditions 15 32 C 59 90 F Transport and storage 25 to 60 C 13 to 140 F Humidity Running conditions Max 80 at 32 C without condensation Min 30 at 15 C to 32 C Nois...

Page 69: ...tem data files or other information determining or affecting system functions can result in erroneous results or equipment failure Only use the control unit that is supplied with the system Control un...

Page 70: ...ly read and displayed on the screen Be sure to hold the head of the hand held barcode reader over the correct barcode label It is recommended to visually verify the displayed scanned characters with t...

Page 71: ...sic software elements 73 Colors 74 Tabs 74 Buttons 75 Lists 76 Organizing lists 76 Sort by column 77 Column header context menu 77 Displaying and hiding columns 77 Filter drop down list 78 Custom Auto...

Page 72: ...4 Software cobas 4800 System Table ofcontents System Manual Roche Diagnostics 72 System Manual Version 1 0...

Page 73: ...avigation bar displays the tabs Choose a tab to open t In the first row of the navigation bar the tabs of the main work areas are displayed In the second row the subtabs belonging to the currently sel...

Page 74: ...n the third row is a subtab of the tab selected in the first row second row Navigating within the software needs only one or two clicks L Choose a main tab in the first tab row Here you have access to...

Page 75: ...riangular markings in text buttons Global action buttons On the right side of the screen the global action buttons are available They are always visible and perform the following functions Button Name...

Page 76: ...gives a general overview Some functions are not available in some of the work areas or less options are available eg in a context menu Organizing Iists The sorting and filtering tools are accessed by...

Page 77: ...l groups to reveal or hide the items they contain C Display a box with a graphic representation of the grouped items Create nested groups by dragging column headings to the display box above the list...

Page 78: ...erion C Click the filter symbol tunnel icon to display the filter context menu Figure 4 6 Filter context menu When a filter criterion is applied its details are displayed in a bar at the bottom of the...

Page 79: ...h current filter on and off C Current filter condition Figure 4 9 Filter control bar For information about filtering in the Resuits work area refer to the test specific Operator s Manual Tool tips pro...

Page 80: ...shed is displayed as a green box The step that is currently in progress is displayed as a blue box Any steps that have not been started are displayed as grey boxes For example a PCR Only run may inclu...

Page 81: ...e purge and archive function to clean up the database To optimize performance It is recommended to purge and archive results older than 6 months For information about the purge and archive function se...

Page 82: ...Workp 22e Reufts Utlidies 1 ki4 o 4 r W 9 9 3 d203f2 0 Roche Diagnostics A List of user activities B Information area Figure 4 14 Audittrail C Changes area You can export the audit trail as a CSV fil...

Page 83: ...Configuration 5 Configuration 85...

Page 84: ......

Page 85: ...onfiguration 87 System settings 87 Reporting 88 Tests 89 Archiving 90 User management 92 Password management 92 Changing a password 92 User account management 93 Creating user accounts 93 Changing use...

Page 86: ...5 Configuration cobas 4800 System Table ofcontents Systeni Manual Roche Diagnostics 86 System Manual Version 1 0...

Page 87: ...d into the following areas System configuration User management System settings Utilities Configuration System settings Use the System settings group to define the parameters found in Table 5 1 Syster...

Page 88: ...automatic log on p r dialog Default vork order file folder Path name Location where the system looks for and saves ivork order files Type the full path and use Windows naming conventions e g C Temp Wo...

Page 89: ...Epot1 tippot d Rt S Figure 5 3 Tests group Parameter Values Comment Test A workflow p r Select a check box to enable a test for use 0fl the system Clear the check box to Test B workflow p F prevent a...

Page 90: ...ed here Ensure that the archive folder is inciuded in the backup plans Contact Roche Service if result archives need to be viewed or restored The purge and archive function only covers run data and re...

Page 91: ...th Location where the resuits are archived The archive folder can be located on a server Type the full path to the archive folder and use Windows naming conventions e g D Archive Allernatively choose...

Page 92: ...e Creating user accounts p 93 Changing a password Any user can change their password Lab managers can change the passwords of all users The password must follow the password rules that are defined in...

Page 93: ...rea User riglits A user assigned to the Operator group has the following user rights Starting and aborting runs Viewing result details and accepting exporting and printing results Performing maintenan...

Page 94: ...he user will be automatically logged off after a certain period of inactivity on the system For more information see Account rules p 96 8 Select the Change password on next log on check box to ensure...

Page 95: ...se the Delete button A confirmation dialog box is displayed 4 Choose the Yes button to confirm the action 0 Unlocking user accounts By default user accounts become locked after five unsuccessful logon...

Page 96: ...tings Item Values Comment minimum number of Number Select or type the minimum number of eharacters characters a password must consist of The minimal required value is automatically set by the system b...

Page 97: ...145 T A 23 l 201214 IS St 231104 20 2 1420 0 1 4 02 110 2022142012 L44 emQ E Figure 59 Export data for Roche Service To export support data 1 Choose Utilities Export support data 2 Select the runs tha...

Page 98: ...e I5NU Ur Epo4ppoid4t4 WT kW F4 F m T 441 448 t 44 28 t 4 Figure 5 10 Viewing the resultcounters To filter the result counter activate the date filter define a date range and choose the Update counter...

Page 99: ...Maintenance 6 Maintenance 101...

Page 100: ......

Page 101: ...information 103 Instrument maintenance 104 Perform start up procedures 105 General cleaning for the instrument 105 Dailymaintenance 105 Weekly maintenance 110 Analyzer maintenance 115 General cleaning...

Page 102: ...6 Maintenance cobas 4800 System Table ofcontents Systern Manual Roche Diagnostics 102 System Manual Version 1 0...

Page 103: ...19 Infection by biohazardous waste p 19 Contamination of the environment by liquid waste and solid waste p 19 Explosion through sparks p 20 fire risk through usage of sprays p 20 Caution messages Pers...

Page 104: ...eate sparks Do not use hot air blowers to dry the instrument NOTICE Instrument damage and malfunction due to incorrect maintenance Perform only the maintenance actions described in the daily and weekl...

Page 105: ...as all carriers should be weekly rinsed with deionized water followed by 70 ethanol The area around the instrument should be periodically checked to ensure that air flow around the instrument is unre...

Page 106: ...the front cover and inspect that all the parts of the instrument or carriers are clean 1f the instrument deck is clean continue with step 6 1f the instrument deck requires cleaning stop daily mainten...

Page 107: ...ding to the appropriate local regulations Replacing large waste bag 1f a waste container is used remove the large waste bag from the waste container and replace it with a new one Close the large waste...

Page 108: ...e the tip eject plate fits horizontally on the initialization waste block 1f it is not placed back properly this may cause a run to crash with instrument malfunction A A Tip eject plate fits horizonta...

Page 109: ...171 4 Roche Diagnostics For the capacitive liquid level detection check the needies are picked up again One channel to the next is checked for the proper functioning of the liquid level detection 1f...

Page 110: ...ee cloths or Q tips Ethanol 70 De ionized water Decontamination liquid NOTICE Infection by biohazardous materials Use proper decontamination liquid according to the advice of Roche Service To perform...

Page 111: ...rtion of the carriers in particular must be checked for cleanliness 8 Choose the 0K button The pipetting arm and the autoloader move to the left hand side of the instrument deck and the next message b...

Page 112: ...used remove the large ivaste bag from the waste container and replace it with a new one Close the large waste bag with a binder and dispose of either waste bag and contents according to the appropriat...

Page 113: ...igure 6 5 Removing waste bag or waste chute p 112 and clean 11 with disinfectant solution Put the clean tip eject plate back in place properly Make sure the tip eject plate fits horizontally on the in...

Page 114: ...3 Clean the autoload protecting ribbon with a lint free cloth soaked in disinfectant solution and wipe without exerting pressure 14 Check the status of the liquid waste container Empty the waste conta...

Page 115: ...tant solution to avoid spreading contamination to laboratory personnel or equipment Handling and disposal of infectious material should be performed according to local safety guidelines General cleani...

Page 116: ...se an immediate burn In its cold state the lamp has a high internal pressure During operation the internal pressure is higher than in the cold state The lamp is extremely unlikely to explode but the p...

Page 117: ...Manual 6 Maintenance Analyzer nrnintenance 2 Move the cover of the analyzer to the right to access to the lamp unit Roche Diagnostics System Manual Version 1 0 4 1 3 Unscrew the lamp unit cover and o...

Page 118: ...ecured by a screw Unscrew the clip and open it 1 Roche Diagnostics I k 0 cbas z 480 A Safety clip B Xenon lamp Figure 6 9 Xenon lamp with clip 5 Press the safety clip to lift the Xenon lamp out of its...

Page 119: ...er of the two expires you will be informed and prompted to exchange the lamp No run can be performed unless the lamp has been replaced 0 Exchanging the ventilation dust filters NOTICE Roche Diagnostic...

Page 120: ...System Systern Manuat To exchange the ventilation dust filters 1 Remove the right instrument panel as shown below to access the lateral ventilation inlet Roche Diagnostics 2 Remove the ventilation dus...

Page 121: ...Figure 6 13 Rearventilation dust filter 4 Remove the used dust filters from each carrier and insert new filters A Dust filter Figure 6 14 Dust filters 5 Replace each dust filter carrier on the corresp...

Page 122: ...onsumer bad FUSES LINE INPUT 2 x T 1OA H 250V Line input analyzer 2 x T 1OA H 250V Table 6 1 Primary fuses To access secondary fuses El F5 remove the right panel of the analyzec Roche Diagnostics Elec...

Page 123: ...T 2 5A 250V Table 6 3 Xenon lamp Roche Diagnostics System Manual Version 1 0 To exchange a primary or secondary fuse 1 Turn off the analyzer then unplug the main cable 2 Unscrew the cover of the fuse...

Page 124: ...ress the clamps of the left and right side of the fuse holder inward PuIl the fuse holder out of its chamber 5 Exchange the blown fuse with a replacement fuse and place the fuse holder back in the cha...

Page 125: ...Troubleshooting 7 Troubleshooting 127...

Page 126: ......

Page 127: ...ms 132 About result flags 134 General troubleshooting 136 Problem reports 136 Remote support 136 LIS troubleshooting 137 Hardware troubleshooting 138 Instrument 138 Barcode reading errors 138 Instrume...

Page 128: ...7 Troubleshooting cobas 4800 System Table ofcontents System Manual Roche Diagnostics 128 System Manual Version 1 0...

Page 129: ...A Iiie alarm area displays the most recent alarms and warnings that are not yet confirmed by the operator Select an alarm in the list and dick the Alarm button on the left to get more details about th...

Page 130: ...ge red icon The error must be resolved before additional samples can be run A problem report is generated automatically iiJ For details about problem reports see Problen reports p 136 Designates a war...

Page 131: ...hey are deleted manually Therefore it is recommended to manually delete confirmed messages from time to time to free up additional space in the database U5o3b04n4n49 0 024 06w A I S nornioon 24 410020...

Page 132: ...ate time Displays the date and time when the message was generated Code Displays the message code Text Displays an abbreviated description of the error or situation that occurred Confirmation Displays...

Page 133: ...sages Alarms or double dick the alarm in the alarm area at the bottom of the screen 2 Select the alarm to be confirmed To select several nonadjacent alarms use the Ctrl key To select a range of adjace...

Page 134: ...rror messages and do not necessarily invalidate the result s Some flags are for information purposes only The flags may originate from either the analyzer the software or the result interpretation Res...

Page 135: ...IIU B C D A Selected result E Result icons B Tab for displaying Flags F Flags column C Flag code G Details area D Flag description Figure 7 4 Example of how to display flag information Each flag is i...

Page 136: ...defined under Utilities Configuration System settings To retrieve a problem report 1 Open Windows File Explorer and go to C ProgramData Roche c48OO ProblemReport 2 Copy the requested problem report to...

Page 137: ...status of the LIS connection Screen Status Comment Not available LIS has been disabled under Ab tyS4s Utilities Configuration LI ts System settings Transferring Data is being transferred to from the L...

Page 138: ...poor quality damaged or missing barcode labels There are several options for handling barcode errors E Exactly follow the procedures outlined below to resolve barcode reading errors Deviating from th...

Page 139: ...ntervention This time the carrier is loaded slower to facilitate barcode reading Choose the Unload carriers button Under the Barcode ID field manually enter the barcode Choose the Reload button 0 Inst...

Page 140: ...session 1 Request a remote support session at Roche Service Roche Service initiates a remote session A message is displayed on screen asking to allow remote access on this computer 2 Confirm the disp...

Page 141: ...ocedure if the system is not used for a longer period of time 1 Perform weekly maintenance of the instrument For details see Weekly maintenance p 110 2 Switch off the instrument and unplug the power c...

Page 142: ...the voltage on the analyzer s type plate corresponds to the local voltage 3 1f the analyzer stili does not function contact Roche Service 0 Red status LEDs 1f the left and right status LEDs glow red...

Page 143: ...Glossary...

Page 144: ......

Page 145: ...right series of tracks into which the autoloader draws carriers LAN Local Area Network The system control unit is connected to the instrument and the analyzer Roche Diagnostics 115 Laboratnry informat...

Page 146: ...lified during PCR Teaching needies Eight titanium pipette tips on the instrument that are used to automatically check of each pipetting channel The teaching needies are stored near the waste station n...

Page 147: ...Index...

Page 148: ......

Page 149: ...acks 55 x480 50 carryover 22 CFR 81 82 changing passwords 92 user accounts 95 circuit breakers 24 cleaning x480 105 z480 115 colors in user interface 74 column header context menus 77 columns displayi...

Page 150: ...4 LIS statuses 137 lists advanced filtering 79 filtering 79 organizing 76 sorting 77 use 76 M magnet plate 57 maintenance daily for x 480 105 weeklyforx 480 110 x480 104 z480 115 managing passwords 92...

Page 151: ...ecovery 140 S safety Roche Diagnostics System Manual Version 1 0 biohazards 19 carryover 22 data security 23 disposal of analyzer 27 disposal of instrument 27 electrical 18 electromagnetic fields 17 e...

Page 152: ...0 teaching needies 46 technical specifications 61 track positions 42 waste container 48 waste station 47 xenon lamp exchanging on z 480 116 z z480 65 block cycler unit 65 detection unit 65 LEDs 67 tec...

Page 153: ...Revisions...

Page 154: ......

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