KrosFlo® Systems
User Guide
16 repligen.com IF.UG.028 R1
7.5
Manual Mode
KrosFlo® Systems can run in a manual mode which will operate the Back Pressure Control Valve (%
Closed), Permeate Pump (RPM), Feed Pump (RPM) and Recirculation Pump (RPM) at constant
settings with no process control.
The Manual mode button must be selected for each device (Pumps and Back Pressure Control Valve)
and appropriate setpoints selected. Setpoints are entered in the BLUE boxes. Once started, KrosFlo®
Systems will maintain setpoint control, however in Manual mode, it will use a constant pump speed
(RPM) or valve setting (% closed), and NOT a process variable control. Once started, KrosFlo®
Systems will maintain setpoint control during operation. Setpoints may be changed during TFF
process operations.
7.6
Settings screen
The Settings screen provides the settings for the
Filter Model
. Selecting a filter model will populate
the
Fiber Count
,
Lumen ID
, and
Surface Area
. These parameters are used for the calculation of shear
and flux. In the event a filter is not listed, the Fiber Count and Lumen ID must be entered in the BLUE
boxes shown in the Filter Model box to ensure correct shear rate data.
Figure 5. Settings screen (Fed Batch disabled)
The Settings screen also allows PID loop tuning of pump response for all pumps. The pump response
to startup and setpoint change can be tailored using PID tuning. Setpoint Data is entered as
described before: navigate to the appropriate Blue box and touch the setpoint box, type in data, and
press ENTER (= equal sign) button on the pop-up keyboard. All setpoint data should be entered prior
to operation. Press
RESET PID TO FACTORY SETTINGS
to return all pumps to their default PID tuning
values.
Press the
Use Weight/Use CF
toggle button to specify whether the Initial and Final Concentration
setpoints are based on the specified weight (Kg) or concentration factor.
