Gambro Cobe Spectra, Essentials Manual

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Introduction
2-2 COBE
®
Spectra™ Apheresis System • Essentials Guide
Spectra System Description
The Spectra system separates and collects blood components from
donors and patients for cell therapy, therapeutic apheresis, and
transfusion medicine applications. The system collects blood products
from donors for transfusion to patients. It can concurrently collect
plasma during platelet and WBC collections for use as plasma, fresh
frozen plasma, or source plasma for further processing into Factor VIII
and Factor IX concentrates.
The Spectra system with software version 5.1 LRS or version 7.0 LRS
Turbo collects leukocyte-reduced, extended life platelets for transfusion.
The system can estimate platelet yields before a platelet collection
procedure starts. This enables users to optimize donor pools by
collecting multiple platelet products from donors with sufficiently high
platelet counts and total blood volumes.
For patients undergoing therapeutic procedures, the Spectra system
exchanges or depletes blood components. In addition, the system
collects platelets and plasma from patients for autologous transfusion.
The Spectra system with software versions 4.7, 5.1, 6.1, and 7.0
processes bone marrow, depletes WBCs, and collects mononuclear cells
and granulocytes (polymorphonuclear cells) from donors or patients.
The Spectra system version 6.1 performs automated peripheral blood
stem cell (PBSC) collection, including low volume collection. The
system can also concurrently collect plasma with PBSCs for use in cell
cryopreservation.
The system uses a Dual-Needle (one access needle and one return
needle) or a Single-Needle (one access/return needle) disposable tubing
set to collect platelets. Operators can convert TPE sets from Dual-
Needle to Single-Needle, if necessary.
The Single-Needle procedure design keeps the extracorporeal volume
low and the process time short. Since the procedure requires one
venipunture for both access and return, it also offers greater comfort for
donors and patients, and is easier for operators to manage.
The Spectra system includes the following:
•
A disposable tubing set, consisting of a separation channel that spins
in the centrifuge to separate blood into its components, and tubing
that routes blood and replacement fluid through the set. See
“Disposable Tubing Sets” on page 2-21 for more information.
•
The COBE Spectra Apheresis System, an automated blood cell
separation device which uses pumps, valves and sensors to control
and monitor the extracorporeal circuit during apheresis procedures.
The software controls pump flow rates and centrifuge speed to
establish and maintain the RBC/plasma interface. The control
panel, including the display screen and keyboard, allows
communication with the Spectra system. The automated system
ensures donor/patient safety while allowing operator control.
Additional features include quick system set-up, automatic tubing
set Prime mode, predictable collection and exchange results,
automatic Rinseback mode, and comprehensive troubleshooting
display screen messages.
Figure 2-1 shows an exterior view of the Spectra system (without a
flow path overlay or disposable tubing set installed).