Part
Function
10
Retentate inlet to tank
Flow path
The feed line transfers liquid from the tank to the filter via the feed pump. The retentate
with particles or molecules too large to pass through the filter pores is returned to the
tank via the retentate line.
Drainage
There are two drain valves. The lower drain valve (before the filter) drains the tank
without passing the filter. The upper drain valve (after the filter) enables flow over the
filter without returning to the tank.
Flow control
The pressure sensor
Pf provides pressure data for the filter feed inlet pressure and
protects the system against overpressure. If the pressure sensor fails, an alarm will be
triggered in the control system.
The
Pf sensor housing also contains the temperature sensor.
The retentate outlet on the filter is connected to the retentate pressure sensor,
Pr. The
transmembrane pressure (TMP) over the filter is controlled via the opening and closing
function of the retentate pressure control valve.
DeltaP
The retentate
ΔP is the difference between the retentate pressure and the feed pres-
sure.
Formula:
ΔP = Pf - Pr
where
Pf is feed pressure
Pr is retentate pressure
4 Flow lines
4.1 Recirculation loop
56
ÄKTA flux s Operating Instructions 29046893 AG
