6.3
Testing filters
Introduction
Before using your ÄKTA flux s and cassette to process a product, the following prepro-
cess procedures must be performed:
1. A filter integrity test
2. A leakage test
3. Clean Water Flux Test
4. Equilibrate flow path with a buffer flush
Filter integrity test
It is recommended to perform a filter integrity test on each filter before usage. Perform
tests according to the filter manufacturer’s instructions. This is usually some form of
air diffusion test using a water wetted filter. Refer to Cytiva integrity test guides
18117269 or 18117173, or your filter manufacturer's instructions.
Leakage test
Follow the instructions below to perform a leakage test:
Step
Action
1
Pressurize the system to the maximum intended process pressure:
a. Tap Feed on the main screen.
b. Use the displayed keypad to set the desired feed pump speed and tap
OK.
For an instruction how to use set-points, see
.
c. Close the retentate valve.
2
Check the system for leaks while maintaining the pressure. Pay special
attention to the filter installation.
3
If leakage is discovered, there might be a cassette, gasket, or surface finish
irregularity present. Proceed as follows:
a. Remove the filters and inspect the sealing surfaces.
b. Correct any problems, reinstall the filters and execute the test again.
6 Run preparations
6.3 Testing filters
108
ÄKTA flux s Operating Instructions 29046893 AG
