Bruker NMR AVANCE NEO Systems, User Manual, Page: 7 / 48

Introduction
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2 Introduction
2.1 AVANCE NMR Spectrometer Intended Use
The Bruker AVANCE systems should only be used for their intended purpose as described in
their respective manuals and outlined in this section.
Use of the unit for any purpose other than that for which it is intended is taken only at the
user’s own risk and invalidates any and all manufacturer warranties. Service or maintenance
work on the consoles must be carried out by qualified personnel. Only those persons
schooled in the operation of Bruker spectrometers should operate the unit.
The Bruker AVANCE systems are ultra high precision spectrometers for the analysis of
chemical structures and molecular properties. Small liquid or solid samples are placed into an
extremely strong magnetic field. They are irradiated with short radio frequency pulses and the
resulting weak transient radio frequencies emitted thereafter by the magnetically active nuclei
(of selected chemical elements) of the samples are then observed. The instrumental
technique is called Nuclear Magnetic Resonance spectroscopy (NMR).
AVANCE spectrometers are available with vertical bore magnets of a field strength between
7 T to over 20 T with room temperature bore sizes between 54 mm and 155 mm. Typical
sample amounts range from nanogram to less than gram level.
The method allows to identify and/or confirm the structure of chemical and biochemical
compounds and mixtures including information concerning molecular mobility and
interactions.
The method is also used to obtain information about the distribution of magnetically active
nuclei within a sample (NMR Imaging, NMR Microscopy).
Typical applications of NMR spectrometers are in all areas of academic and industrial
research and quality control in the fields of materials science, organic chemistry, inorganic
chemistry, and in the analysis of biological samples.
The AVANCE spectrometer line can be equipped/connected with a large variety of optional
accessories such as:
• Variable temperature control
• MAS pneumatic control to enable fast sample rotation
• Variable magnetic field gradients
• Flow-Through and HPLC equipment and according accessories
• Automatic sample changers
• Automatic sample preparation
• Special ultra low temperature probes (CryoProbes and their accessories)
AVANCE spectrometers are not designed primarily for:
• Investigations of ferromagnetic materials.
AVANCE Spectrometers are not approved for diagnostic purposes in the medical field such
as IVD according to legal requirements.