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Bruker InsightMR, User Manual

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InsightMR

User Manual

Version 003

Innovation with Integrity

●

NMR

Summary of Contents for InsightMR

Page 1: ...InsightMR User Manual Version 003 Innovation with Integrity NMR...

Page 2: ...or registered trademarks of their re spective holders This manual was written by InsightMR team February 07 2017 Bruker Corporation Document Number 10000054012 P N H155936 For further technical assist...

Page 3: ...19 5 1 Symbols on the Packaging 19 5 2 Inspection at Delivery 20 5 3 Packaging 20 5 4 Storage 21 6 Flow Unit Installation 23 6 1 Choose the Position of the Reactor 23 6 2 Connecting the Transfer Line...

Page 4: ...be Used 45 9 Flow Tube Assembly Removal Checklist 47 9 1 Prepare the Flow Tube Assembly 47 9 2 Remove the Flow Tube Assembly 47 9 3 Storage 48 9 4 Prepare the NMR System 48 9 5 The system is ready for...

Page 5: ...ruker s policy to improve products as new techniques and components become available Bruker reserves the right to change specifications at any time Every effort has been made to avoid errors in text a...

Page 6: ...e of not following the warning 1 This is the safety condition u This is the safety instruction NOTICE NOTICE indicates a property damage message This is the consequence of not following the notice 1 T...

Page 7: ...ows the transfer of liquid from an external container through a transfer line into the NMR detection area and back Once the liquid is in the detection area NMR data can be acquired either under static...

Page 8: ...ble at the time of the conclusion of the contract shall apply 2 4 Copyright All rights reserved This manual is protected by copyright and intended solely for internal use by customers This manual must...

Page 9: ...erating instructions if necessary The system owner must clearly lay down and specify responsibilities with respect to installation operation troubleshooting maintenance and cleaning The system owner m...

Page 10: ...less condition Therefore the following applies The system owner must ensure that the maintenance intervals described in this manual are observed The system owner must ensure that all electrical mechan...

Page 11: ...Cease work while unauthorized persons are in the danger and working zone 3 2 2 Instruction Personnel must receive regular instruction from the owner The instruction must be documented to facilitate im...

Page 12: ...f sample liquid must be possible using standard safety equipment goggles lab coat gloves etc CAUTION Risk of injury from broken glass during glass flow tube replacement Incorrect handling of the glass...

Page 13: ...as a result of flow unit leakage may result in material damage to the NMR probe u Do not apply pressure above 10 bar to the flow unit assembly u Before introducing the flow tube assembly in the magnet...

Page 14: ...ontamination from toxic liquids or vapors may result after a glass flow tube breakage or from leakage of sealing O rings or connectors u Wear proper personal protective equipment Examples include but...

Page 15: ...rface with an isolation valve on the other end 1 2 3 4 5 6 Figure 4 1 InsightMR Flow Tube Assembly and the Transfer Line 1 Sample Lines 4 Glass Flow Tube 2 Temperature Control Lines 5 Tube Holder 3 Th...

Page 16: ...mple in and sample return and 2 concentric temperature control lines surrounding the sample lines Thermostatic liquid is flushed through the temperature control lines to maintain the temperature durin...

Page 17: ...and data processing features enabling on the fly acquisition parameter adjustment based on real time kinetic data Please refer to the section Software Installation 27 for instructions on the software...

Page 18: ...Design and Function 18 H155936_3_003...

Page 19: ...amaged Fragile Marks packages with fragile or sensitive contents Handle the package with care do not allow the package to fall and do not allow it to be impacted Protect Against Moisture Protect packa...

Page 20: ...or only accept it subject to reservation Note the extent of the damage on the transport documentation or the shipper s delivery note Initiate complaint procedures Issue a complaint in respect to each...

Page 21: ...moving the Flow Unit for Storage in the Transport Box 41 Close the inlet and outlet of the sample line to protect the system against dust and dirt Leave the glass flow tube connected to tube holder Pr...

Page 22: ...Transport Packaging and Storage 22 H155936_3_003...

Page 23: ...ion vessel rated for chemical waste according to local EH S standards below the NMR probe with sufficient volume to contain the thermostat liquid and the reaction mixture in the unlikely case of a lea...

Page 24: ...SampleJet 6 3 Testing the Flow Unit Prior to Inserting it into the Magnet Figure 6 3 The InsightMR Flow Unit From left to right the pump the reactor the flow tube assembly secured with a clamp stand...

Page 25: ...ft to Right Glass Flow Tube O Rings Vessel Connections and Flow Interface Valve Connect the vessel to the pump 1 Connect the pump outlet to the flow interface valve inlet 2 adjacent to the green conne...

Page 26: ...to the target temperature start it and wait for the desired temperature to be reached Verify that the temperature control liquid returns to the chiller Check for leakages at the upper part of the sam...

Page 27: ...Once the software is installed the host ID is visible under the Help About tab InsightMR software installation InsightMR must be installed together with the TopSpin s and IconNMR s versions included...

Page 28: ...th Install Bruker NMR Software and Install GPL licensed Cygwin 1 7 4 Software checked will appear Click Next Figure 6 7 Selection of Components to Install The TopSpin release letter will appear and a...

Page 29: ...does not Exist Choose Customized setup type Figure 6 11 Select Setup Type Click on More information to see the current installed versions vs the new ones for the different software parts Select at le...

Page 30: ...low Unit Installation 30 H155936_3_003 Figure 6 12 Select Products to Install Select the NMR Super User It could be one of the domain users or traditionally nmrsu Figure 6 13 Select the NMR Super User...

Page 31: ...xt message window by clicking Next The installation will start If the installation has been successful you will see two messages similar to those below with all steps in green If it is a windows insta...

Page 32: ...on Check Once Expinstall is complete configure IconNMR as described in the next section 6 6 2 InsightMR Flow Mode Configuration If not launched already launch InsightMR by clicking on the desktop Icon...

Page 33: ...the Icon Configuration In TS3 5 pl6 and beyond switch off the domain users if you are not going to use them since they slow down the program Uncheck anything under Domain Options Resource File Settin...

Page 34: ...e of InsightMR To restore defaults click on File Restore Defaults Flow Tube InsightMR Figure 6 21 Restoring the Default Settings 6 6 2 1 Recommended Settings This section lists the recommended setting...

Page 35: ...tup Mode should be checked Figure 6 23 Configuring the Automation Window Automation Solvent Probe Dependencies Non deuterated solvents must have XAU lctshim flow and LOCK OFF as Associated Shim and Lo...

Page 36: ...and match after a solvent change Figure 6 25 Selecting the Tuning and Matching Options Settings for Solvents Should protonated solvents such as CH2Cl2 CH3CN DMSO H6 be missing from the Solvent tab in...

Page 37: ...ort Solvents and import the new solvent file C Bruker TopSpinHOME exp stan nmr lists solvents xml One could also select the Restore Default Solvents option but this would DELETE any solvent previously...

Page 38: ...under the help button Manuals in TopSpin to add the new solvent and its properties in the edlock table Ensure the new solvent will also be shown in IconNMR Non deuterated solvents must have XAU lctsh...

Page 39: ...perature before inserting the glass flow tube Inspect the flow unit looking for condensation especially around the glass flow tube tube holder and holder body Wipe any observed condensation 7 1 Insert...

Page 40: ...on of InsightMR launch the program by clicking on the InsightMR desktop Icon Refer to the InsightMR quick start guide under Help QuickStart for instructions on how to use the software Under Help there...

Page 41: ...and empty the liquid through the outlet into the chiller Flush with compressed air to speed the process up Visually inspect the glass flow tube for damage contamination and leaks The glass flow tube...

Page 42: ...Operation 42 H155936_3_003...

Page 43: ...BESTPROFILE from TopSpin 4 Remove the sample from the magnet 5 Deactivate the sample changer if there is any 6 Set the Sample Changer Automation Mode to Flow Tube InsightMR in the IconNMR configuratio...

Page 44: ...the set temperature is in the recommended range for the probe and the flow unit 5 Verify that the thermostatic liquid returns to the thermostat Ensure that the liquid level remains stable 6 Check for...

Page 45: ...ube seats on the probe To ensure proper insertion lift it 1 cm up and push it back down You must feel a solid resistance 4 Optionally acquire a BESTPROFILE and compare the result to that obtained from...

Page 46: ...Flow Tube Assembly Insertion Checklist 46 H155936_3_003...

Page 47: ...low tube assembly and transfer lines to a clamp stand ideally in the fume cupboard 3 Disconnect the sample supply connect a syringe to the outlet of the sample line and empty the flow path by flushing...

Page 48: ...original transport box 9 4 Prepare the NMR System 1 Activate the sample changer 2 Set the temperature of the NMR probe and the gas flow back to normal values 3 Remove the transfer line holder from th...

Page 49: ...the surface or inside the glass flow tube Follow these instructions to safely remove the glass flow tube from the tube holder Turn the twist cap 90 Pull it off the glass flow tube together with the O...

Page 50: ...ow tube protector Squeeze it gently until you feel some friction and push the glass flow tube with a slight turn over the two O rings of the tube holder rod Push the tube with the tool to the far end...

Page 51: ...ronmental protection regulations 11 2 Disposal Europe Environmental information for laboratory and industrial customers within the EU European Union This laboratory product is developed and marketed f...

Page 52: ...012 19 EU WEEE 2 Bruker BioSpin offers to take back the equipment only for deliveries after 23 03 2006 after termination of use at the customer site upon request by the customer This request must be a...

Page 53: ...25 HE at 5 C is 4 C and at 60 C is 2 C remark the loss is very dependent on the flow power a thermostat can create therefore these numbers are based on the thermostat type we recommend The unit can be...

Page 54: ...Technical Data 54 H155936_3_003...

Page 55: ...hotlines and service centers so that our specialists can respond as quickly as possible to all your service requests applications questions software or technical needs Please select the NMR service ce...

Page 56: ...Contact 56 H155936_3_003...

Page 57: ...29 Figure 6 11 Select Setup Type 29 Figure 6 12 Select Products to Install 30 Figure 6 13 Select the NMR Super User 30 Figure 6 14 Select an NMR Administration Password 31 Figure 6 15 Installation Fin...

Page 58: ...List of Figures 58 H155936_3_003...

Page 59: ...H155936_3_003 59...

Page 60: ...Bruker Corporation info bruker com www bruker com Order No H155936...

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