3Brain BioCAM X, User Manual

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9
Overview
The BioCAM X platform is a high resolution electrophysiology system capable to perform in-vitro elec-
trophysiological measures on electroactive cells and tissues. Even though, to some extents, the plat-
form has some similarities with more conventional Microelectrode Array (MEA) systems, it is a radically
new technology to perform extracellular measures. Differently than conventional MEA systems, the
BioCAM X platform relies on active CMOS-MEA chips, which integrate thousands of miniaturized active
electrodes over large areas. Combined to sub-millisecond temporal resolution, the dense integration of
electrodes results in a spatial resolution that enables novel analysis, can increase the statistical signif-
icance of your experiments and opens new imaging approaches to investigate electroactive prepara-
tions.
The 3Brain’s BioCAM X platforms was tested so far for in-vitro electrophysiological experiments on
neuronal cell cultures, brain slices, retina preparations and cardiac cultures. Electrophysiological signals
ranging from slow field potentials to fast single cell spiking activity can be recorded simultaneously.
Examples of recordings provided by different laboratories using the BioCam platforms are available on
the 3Brain website and uploads of novel examples based on your research are warmly welcome.
Overall, the platform consists of three basic components: A) a multiuse BioChip cartridge available in
different models and incorporating the CMOS-MEA silicon chip; B) the acquisition BioCAM X hardware
that reads out electrophysiological signals from the BioChip; C) the host PC equipped with the acqui
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sition board and the BrainWave X software to acquire, visualize, store and analyse experimental data
recorded with the BioCAM X platform.